Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length495 amino acids

Chemical FormulaC2553H3937N637O704S25

DescriptionStandard

        MHIQIHTTVKATTFDHFSWLCRSVVMDKMQLIALLLVTVTHTHANYSAMQAVLSQKGLQKVSHWLTDWLQSKLSTIKLPEVRGDVDIKIGKVHYFLHDMSIQRCDLPEPSVAFSEGTGISLQVDGLSIAIQGRWDTYFGIIHDSGWFNLVVYTINLNTVLQLGSDNGHLSISTAVCSADVGSVQVHFHGGASFIFQPFVTMFSWKIRDGIHEKICAAFEQRIEAIDGYLAAMPDAINMDPYVFMNISLTDSPIVMYSALGLNVTGEFYSINFPSEPPFSPNRFQMPWQNNYMLSVGTSEFCINSAAYAYHKSGVLYILIKDDMIPKTYPFHLNTNQFGILIPQLPKFYPNLTMKVLLYASDPPFFSFTEKAINIHLFAAAKFFAIKADTEVPLFRLDMECSFSTKASIDKQLLKGVLQMKNLTMTLGATEIGDFPIAPIKNVVTFALTKKVLPKVNAQLKDGLPLPVVKDFTLKNSVMTIENVSKIHMRDLFHIY
    

Molecular Weight55619.04 Da

Isoelectric Point (pI)6.80

Net Charge (pH 7.0)-0.97

Net Charge (pH 7.4) -2.29

Charge Density (pH 7.0) -0.0020

GRAVY Index0.16

Hydrophobic Moment 0.59

Boman Index0.18

Instability Index39.49

Aliphatic Index 96.89

Aromaticity 0.1131

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103818 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence