Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length349 amino acids

Chemical FormulaC1752H2734N486O492S13

DescriptionStandard

        MMARPYYMVVALLLLAEFTRFGEGTPNPGFMVRITGKGLEYAHQYGVATLKNDLSTIKLPDLSGSYGIGWLGSVNYVFSGMRIHHFLLRNSQLSLHPRQGIKASLSNNHVSVSGNWKVKKSFITLHGTFDLSVDGMSVLVSLNLDKDQSGRPTVSVTHCHNFIGHVSIEISGHISWILNLFHERIENNVKNILEQKICKMVKESAASRLEPYLRTLPVTSMIDQIAGIDYRLVGAPQVTFQGLDTPFKGEFFGRNWNSSVPFDAPPIMLPQKHDHMIYFAVSEYVFNTASRVYHQAGQMKFTIQNKHVSRGGKRLGVPGEKIRWDSRSTVSALGSQEKNVAFGASQIGV
    

Molecular Weight38894.25 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)11.81

Net Charge (pH 7.4) 10.73

Charge Density (pH 7.0) 0.0338

GRAVY Index-0.13

Hydrophobic Moment 0.84

Boman Index0.08

Instability Index37.65

Aliphatic Index 88.19

Aromaticity 0.0974

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0172910 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyBPI/LBP

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria