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MYP_078295
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Basic Information
CA(1-7)-Hecate11/23
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C119H211N31O21
Standard
Sequence
KWKLFKKALKKLKKALKKAL
Physicochemical Analysis
2412.14 Da
10.95
9.75
9.53
0.4875
-0.64
0.80
-0.29
-19.24
112.50
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
892.21
-0.84
32.0
31.0
93.0
171.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261980 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
18 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0288249 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human breast adenocarcinoma MCF-7
5 μM
EC50
PMID29679519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29679519/
RECORD: Rec_0299013 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human prostate adenocarcinoma PC-3
18 μg/mL
LD50
PMID29679519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29679519/
RECORD: Rec_0312658 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
130 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0312766 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CA-MA / CA-ME / cecropin-magainin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
H-1299
52.0 μg/mL
LD50 / MTT-MTS assay
PaperCancerPPD exact sequence record; CA/Hecate hybrid
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