‹ ›
MYP_078281
← PREVIOUS NEXT → BACK
Basic Information
Palustrin-1d
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
27 amino acids
C125H228N34O34S3
Standard
Sequence
ALSILKGLEKLAKMGIALTNCKATKKC
Physicochemical Analysis
2847.55 Da
9.79
4.77
4.54
0.1768
0.32
0.75
0.07
9.63
115.93
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1117.12
-9.45
41.0
42.0
104.0
196.0
0.0
27.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0002945 VERIFIED: NO
Provenance & Taxonomy
American frog [Animal]
Palustrin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
21-27
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0076618 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0118281 VERIFIED: YES
Provenance & Taxonomy
Rana palustris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
21-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
28 μM
MIC
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0212968 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Palustrin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
21-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
28.0 μM
MIC
PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0214113 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
1 2 3 NEXT LAST
Showing 5 records on this page · Page 1 of 3