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MYP_078271
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Basic Information
Japonicin-2OM1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C116H190N26O24S2
Standard
Sequence
FIVPSIFLLKKAFCIALKKNC
Physicochemical Analysis
2397.04 Da
9.70
3.74
3.50
0.1779
1.17
0.50
0.33
14.37
134.76
0.1429
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
803.93
-1.46
29.0
30.0
80.0
168.0
4.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0187261 VERIFIED: YES
Provenance & Taxonomy
Rana omeimontis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
19 μM
MIC
PMID25001915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25001915/
RECORD: Rec_0188403 VERIFIED: YES
Provenance & Taxonomy
Rana omeimontis [Animal]
Omeimontisin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-21
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/E1AZ76/entry
RECORD: Rec_0193597 VERIFIED: YES
Provenance & Taxonomy
Rana omeimontis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium 091299
75 μM
MIC
PMID25001915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25001915/
RECORD: Rec_0203702 VERIFIED: YES
Provenance & Taxonomy
Rana omeimontis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0225395 VERIFIED: YES
Provenance & Taxonomy
Rana omeimontis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis 981
75 μM
MIC
PMID25001915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25001915/
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