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MYP_078188
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Basic Information
Gomesin c(1-18)[Gln1]
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C93H158N36O24S4
Standard
Sequence
QCRRLCYKQRCVTYCRGR
Physicochemical Analysis
2292.74 Da
9.93
5.72
5.45
0.3176
-1.06
0.47
-0.64
36.59
37.78
0.1111
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1040.41
-12.05
44.0
34.0
77.0
157.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0215896 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
2-15, 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic
Erwinia carolovora
3.15-6.25 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
RECORD: Rec_0221557 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
2-15, 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic
Aerococcus viridans
0.8-1.6 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
RECORD: Rec_0232320 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Tachyplesin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
A. brassicola, A. fumigatus, Fusarium culmorum, Fusarium oxysporum, N. crassa, N. haematococca, T. viridae, T. mentagrophytes; yeasts Candida albicans, C. tropicalis, Cryptococcus neoformans, Saccharomyces cerevisiae
0.4-6.2 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.
RECORD: Rec_0247648 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Tachyplesin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
C. glabrata, and B. bassiana
12.5-25 μM
MIC
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.
RECORD: Rec_0250621 VERIFIED: YES
Provenance & Taxonomy
Acanthoscurria gomesiana [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
2-15, 6-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic
Xhantomonas campestris pv
PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
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