Peptide Database

Peptide NameGomesin c(1-18)[Gln1]

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC93H158N36O24S4

DescriptionStandard

        QCRRLCYKQRCVTYCRGR
    

Molecular Weight2292.74 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3176

GRAVY Index-1.06

Hydrophobic Moment 0.47

Boman Index-0.64

Instability Index36.59

Aliphatic Index 37.78

Aromaticity 0.1111

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1040.41

LogP -12.05

H-bond Donors 44.0

H-bond Acceptors 34.0

Rotatable Bonds 77.0

Heavy Atoms 157.0

Ring Count 2.0

Amide Bonds 19.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0077234 VERIFIED: YES

Provenance & Taxonomy

OrganismAcanthoscurria gomesiana [Animal]

FamilyGomesin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

RECORD: Rec_0078877 VERIFIED: YES

Provenance & Taxonomy

OrganismAcanthoscurria gomesiana [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Disulfide2-15, 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic

TargetBacillus cereus

Activity6.25-12.5 μM

MethodMIC

PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/

RECORD: Rec_0080594 VERIFIED: YES

Provenance & Taxonomy

OrganismAcanthoscurria gomesiana [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Disulfide2-15, 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic

TargetFusarium oxysporum

Activity0.4-0.8 μM

MethodMIC

PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/

RECORD: Rec_0091006 VERIFIED: YES

Provenance & Taxonomy

OrganismAcanthoscurria gomesiana [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Disulfide2-15, 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic

TargetCandida tropicalis

Activity3.15-6.25 μM

MethodMIC

PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/

RECORD: Rec_0094006 VERIFIED: YES

Provenance & Taxonomy

OrganismAcanthoscurria gomesiana [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Disulfide2-15, 6-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiparasitic Antimalarial Antic

PaperIsolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem. 2000 Oct 27;275(43):33464-70. doi: 10.1074/jbc.M001491200. PMID: 10942757. PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/

FIRST PREV 1 2 3 4 5 ... 13 NEXT LAST

Showing 5 records on this page Ã‚Â· Page 3 of 13