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MYP_078141
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Basic Information
Ocellatin-PT7
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
32 amino acids
C146H246N42O42S
Standard
Sequence
GVFDIIKGAGKQLIAHAMGKIAEKVGLNKDGN
Physicochemical Analysis
3293.84 Da
9.40
1.85
1.58
0.0577
-0.01
0.59
0.13
1.80
103.75
0.0312
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1365.37
-12.68
45.0
46.0
118.0
231.0
2.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075660 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pustulatus [Animal]
Ocellatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Staphylococcus aureus ATCC 29313
800 μg/mL
MIC
PMID26107622;27463422 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26107622/
RECORD: Rec_0078833 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pustulatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
Staphylococcus aureus ATCC 29313
240 μM
MIC
PaperCharacterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus
RECORD: Rec_0130606 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0136049 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pustulatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-positive
Staphylococcus aureus
240 μM
MIC
RECORD: Rec_0153948 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus pustulatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
it has leishmanicidal activity
72.8 μM
IC50
PaperCharacterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus
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