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MYP_078029
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Basic Information
Vigno 5
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C117H187N35O38S6
Standard
Sequence
GLPLCGETCVGGTCNTPGCSCGWPVCVRN
Physicochemical Analysis
2884.34 Da
5.96
-0.30
-0.59
-0.0102
0.32
0.29
0.21
30.36
56.90
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1133.84
-16.34
44.0
44.0
84.0
196.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010696 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant],Viola ignobilis [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human cervical carcinoma HeLa
10 μM
PaperCharacterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry | PubMed PMID 26751970 | Hashempour et al., 2013 | Esmaeili et al., 2016 | Farhadpour et al., 2016 | Hellinger et al., 2015 PMID26751970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26751970/
RECORD: Rec_0078114 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0089794 VERIFIED: YES
Provenance & Taxonomy
Plantae [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID26751970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26751970/
RECORD: Rec_0211125 VERIFIED: YES
Provenance & Taxonomy
Viola ignobilis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
cancer cells: Hela. MOA: the peptide induces apoptosis by releasing cytochrome C
PaperViola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells
RECORD: Rec_0267014 VERIFIED: YES
Provenance & Taxonomy
Plantae [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID26751970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26751970/
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