Peptide Database

Peptide NameBeta-defensin 125 (Beta-defensin 25) (DEFB-25) (Defensin; beta 125)

Function Ontology

Antimicrobial

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length156 amino acids

Chemical FormulaC762H1211N203O242S14

DescriptionStandard

        MNILMLTFIICGLLTRVTKGSFEPQKCWKNNVGHCRRRCLDTERYILLCRNKLSCCISIISHEYTRRPAFPVIHLEDITLDYSDVDSFTGSPVSMLNDLITFDTTKFGETMTPETNTPETTMPPSEATTPETTMPPSETATSETMPPPSQTALTHN
    

Molecular Weight17536.89 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-5.19

Net Charge (pH 7.4) -5.74

Charge Density (pH 7.0) -0.0333

GRAVY Index-0.31

Hydrophobic Moment 0.60

Boman Index0.00

Instability Index69.79

Aliphatic Index 69.36

Aromaticity 0.0641

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7074.98

LogP -78.45

H-bond Donors 251.0

H-bond Acceptors 255.0

Rotatable Bonds 560.0

Heavy Atoms 1221.0

Ring Count 29.0

Amide Bonds 164.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145742 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyBeta-defensin; Defensin

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Non-hemolytic