Peptide Database

Peptide NameB3(derived from Uperin 2.7)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC73H114N16O19

DescriptionStandard

        GIIDIAKKLFESW
    

Molecular Weight1519.78 Da

Isoelectric Point (pI)6.07

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0183

GRAVY Index0.38

Hydrophobic Moment 0.66

Boman Index0.27

Instability Index10.98

Aliphatic Index 127.69

Aromaticity 0.1538

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 575.18

LogP -1.39

H-bond Donors 20.0

H-bond Acceptors 19.0

Rotatable Bonds 51.0

Heavy Atoms 108.0

Ring Count 3.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0299246 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targeted Human Immunodeficiency Virus Type 1 HIV-1

Activity20.1 μM

MethodEC50

RECORD: Rec_0385000 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 IIIB | CEM-SS cells

Activity20.1 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/

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