Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length467 amino acids

Chemical FormulaC2324H3674N588O667S16

DescriptionStandard

        MEMACRLTLALSLAMFVGATNMNPGFVVRLTQKGLDYARQEGMAVLQQELSKIHLPDFSGSTKIAHIKAKYSFNSMVIRSFQIPSSQISLVPNVGLKLSISGAFIQVDGKWNAHYLVSDKGNFDLKVEGLSISVGLQLGSDASGRPTISSSDCSCHISDVKIHVSGKFRWLVDVFHKSIDNALRKAIEGQLCPVVTQSITNKLQPLLQTLPVTAQIDHVAAIDYSLTGPPTVTAQSLDVQLKGEFFDIAHRTTPPFSPPPVPLPAEQNLMVYFGVSDYLFNTAGYAYYSAGKFESYITDDMIPKNFSVHLNTSSFGILIPQLSKMYPNMPMILKIYTPSAPFLTIEPGNLTTSPIVAIQAYVQFPNASLAPLFLLNLTTTVLVKVSVNSGRIVGSLELSRIKMELVHSDVGPFPVGILNTVVNYYISSIILPEVNEILQKGYPLPLLDHIQLTDVIIKPSEGIHSVQ
    

Molecular Weight51036.61 Da

Isoelectric Point (pI)6.86

Net Charge (pH 7.0)-0.47

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0010

GRAVY Index0.20

Hydrophobic Moment 0.78

Boman Index0.19

Instability Index44.32

Aliphatic Index 105.78

Aromaticity 0.0835

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 35090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0295110 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria