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MYP_077760
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Basic Information
Ruminococcin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
24 amino acids
C119H180N32O35S4
Standard
Sequence
GNGVLKTISHECNMNTWQFLFTCC
Physicochemical Analysis
2747.16 Da
6.72
-0.18
-0.48
-0.0075
0.09
0.43
0.17
1.61
60.83
0.1250
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1093.69
-11.66
40.0
40.0
88.0
190.0
5.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0300809 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
R. obeum ATCC 29174
32.5 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0305897 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
C. botulinum
75 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0331246 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
E. contortum ATCC 25540
32.5 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0367583 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
C. difficile serogroup A B-1
75 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0378901 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium],Ruminococcus hansenii [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
① It is highly probable that (i) Ser9 and the putative Cys23 and (ii) the putative His22 and Thr24 are associated in a Lanthionine (Lan) and a 3-methyllanthionine (Me-Lan) residue, respectively. ②The residues at position 7 and 16 are (Z)-2,3-didehydrobutyrine (Dhb)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Clostridium difficile serogroup A B-1
75 μg/mL
MIC
PMID11526013;11741840;12089024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11526013/
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