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MYP_077760
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Basic Information
Ruminococcin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
24 amino acids
C119H180N32O35S4
Standard
Sequence
GNGVLKTISHECNMNTWQFLFTCC
Physicochemical Analysis
2747.16 Da
6.72
-0.18
-0.48
-0.0075
0.09
0.43
0.17
1.61
60.83
0.1250
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1093.69
-11.66
40.0
40.0
88.0
190.0
5.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0235788 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium],Ruminococcus hansenii [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
① It is highly probable that (i) Ser9 and the putative Cys23 and (ii) the putative His22 and Thr24 are associated in a Lanthionine (Lan) and a 3-methyllanthionine (Me-Lan) residue, respectively. ②The residues at position 7 and 16 are (Z)-2,3-didehydrobutyrine (Dhb)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
gnavus ATCC 29149
75 μg/mL
MIC
PMID11526013;11741840;12089024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11526013/
RECORD: Rec_0242890 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
C. difficile serogroup C C253
75 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0282233 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0289567 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
C. bifermentans
75 μg/mL
MIC
PaperRuminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces
RECORD: Rec_0299322 VERIFIED: YES
Provenance & Taxonomy
Ruminococcus gnavus [Bacterium],Ruminococcus hansenii [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
① It is highly probable that (i) Ser9 and the putative Cys23 and (ii) the putative His22 and Thr24 are associated in a Lanthionine (Lan) and a 3-methyllanthionine (Me-Lan) residue, respectively. ②The residues at position 7 and 16 are (Z)-2,3-didehydrobutyrine (Dhb)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
bifermentans NCTC 506
75 μg/mL
MIC
PMID11526013;11741840;12089024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11526013/
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