Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ CaMKII Inhibitory

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC74H121N23O20

DescriptionStandard

        KKKLRRQEAFDAY
    

Molecular Weight1652.89 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.2123

GRAVY Index-1.72

Hydrophobic Moment 0.25

Boman Index-0.64

Instability Index100.70

Aliphatic Index 45.38

Aromaticity 0.1538

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 752.30

LogP -5.99

H-bond Donors 27.0

H-bond Acceptors 23.0

Rotatable Bonds 59.0

Heavy Atoms 117.0

Ring Count 2.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310646 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAIP

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

CaMKII Inhibitory

TargetCalmodulin-dependent protein kinase II (CaMKII)

PaperIshida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett., 427, 115-118 (1998). PMID9613610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9613610/