Peptide Database

Peptide NameBombinin-H1/H3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC92H165N23O23S

DescriptionStandard

        IIGPVLGMVGSALGGLLKKIG
    

Molecular Weight1993.50 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.0837

GRAVY Index1.34

Hydrophobic Moment 0.49

Boman Index0.55

Instability Index12.44

Aliphatic Index 162.38

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 708.80

LogP -3.95

H-bond Donors 24.0

H-bond Acceptors 26.0

Rotatable Bonds 68.0

Heavy Atoms 139.0

Ring Count 1.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0024778 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina variegata [Animal]

FamilyBombinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetHas hemolytic activity against human erythrocytes

MethodHemolysis

RECORD: Rec_0037416 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina variegata [Animal]

FamilyBombinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

RECORD: Rec_0198014 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial

RECORD: Rec_0213415 VERIFIED: NO

Provenance & Taxonomy

OrganismBombina variegata [Animal]

FamilyBombinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Cytolytic Hemolytic Non-ribosomal

MethodQualitative functional evidence

RECORD: Rec_0332235 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina variegata [Animal]

FamilyBombinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli