Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2377H3708N610O674S17

DescriptionStandard

        MDFAYRLTLLFSIAAFVGTADAENPGLVVRVTQKGLDYALQEGVIALQQQLSHIQLKDIPGTHNHEIVGKVHYNIFSMNLGNFQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVQHSFVHENGTFNIKVGGLGMSVGLNLRNIEHGKPTVSVADCSCHIANVEVHMSGTIGWLVKLFHDAVESKIRQELEDKICPEINDIINSKLSSLLQTLPVETNLDHISALDYSLMGPPSVMANWVDVFLKGEFFYRSHRTAPPFAPPAMSLPPEQDHMVYFAVSDYVFNTALLAYQSARALVLTLTDKMIPKEFGVHLNTNLLERVIPAVSKMYPNMPMKLKISAASTPALNITPGGVTLSPIGNFQAYAILPNSSLAPLFLLEVKTNAFAKAAVNSGKIVGTLENGKVEVSLSHSDVGPFSVSEINMAMNLLVPVILPHINDYLKYGFPLPLIEHIQLSDIVIKTYEHYLLFGANVQYQ
    

Molecular Weight52159.65 Da

Isoelectric Point (pI)6.04

Net Charge (pH 7.0)-7.92

Net Charge (pH 7.4) -9.19

Charge Density (pH 7.0) -0.0167

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index42.84

Aliphatic Index 103.81

Aromaticity 0.0884

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221137 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria