Peptide Database

Peptide NameSLAY-screened peptide P1190

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC115H175N29O28

DescriptionStandard

        APLWPHQGLSRFSILFITITN
    

Molecular Weight2411.80 Da

Isoelectric Point (pI)9.80

Net Charge (pH 7.0)0.88

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0420

GRAVY Index0.48

Hydrophobic Moment 0.40

Boman Index0.33

Instability Index41.16

Aliphatic Index 116.19

Aromaticity 0.1429

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 901.21

LogP -5.64

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 72.0

Heavy Atoms 172.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0171995 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/