Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length522 amino acids

Chemical FormulaC2681H4205N679O750S18

DescriptionStandard

        MMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGVEMIEQMVKERKIPDLKGSESPKFLKIDYMNYKLINIKINAFSLPNTSLAFVPGVGIRALIKHGTANISTDWEIKSPLFQDTGGANLLLSGVYFTGILVLARNDFGHPILKLQDCNAQVSRNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEALNANLSMLEVLRSVDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKKIFNHLIRNSQGLGNMLSWIAELYILSQPFMVQVLAREPPVVNLLPGHFTLDIPASFVILTQSKNSTAETVLSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESIRSNIEVFRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSLKQQSSFHGWEALNLIRGRWRGKPAPWLPVWSPLQEVNRP
    

Molecular Weight58526.33 Da

Isoelectric Point (pI)7.63

Net Charge (pH 7.0)1.20

Net Charge (pH 7.4) 0.38

Charge Density (pH 7.0) 0.0023

GRAVY Index0.13

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index45.19

Aliphatic Index 107.39

Aromaticity 0.1015

Extinction Coeff. Reduced 69330.00

Extinction Coeff. Oxidized 69580.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0110274 VERIFIED: NO

Provenance & Taxonomy

OrganismTursiops truncatus [Animal]

FamilyBPI

Tax ID9739

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence