Peptide Database

Peptide NameBeta-insect depressant toxin LqhIT2

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC291H433N79O92S8

DescriptionStandard

        DGYIKRRDGCKVACLIGNEGCDKECKAYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
    

Molecular Weight6766.55 Da

Isoelectric Point (pI)5.17

Net Charge (pH 7.0)-1.31

Net Charge (pH 7.4) -1.66

Charge Density (pH 7.0) -0.0215

GRAVY Index-0.65

Hydrophobic Moment 0.55

Boman Index-0.05

Instability Index41.89

Aliphatic Index 41.64

Aromaticity 0.1311

Extinction Coeff. Reduced 27960.00

Extinction Coeff. Oxidized 28460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2767.79

LogP -29.23

H-bond Donors 106.0

H-bond Acceptors 99.0

Rotatable Bonds 219.0

Heavy Atoms 470.0

Ring Count 13.0

Amide Bonds 62.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016263 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus quinquestriatus hebraeus [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide10-60; 14-35; 21-42; 25-44

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense