‹ ›
MYP_077044
← PREVIOUS NEXT → BACK
Basic Information
SARS-CoV-2 HR1P
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
42 amino acids
C187H314N56O65
Standard
Sequence
ANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ
Physicochemical Analysis
4386.83 Da
8.54
0.80
0.60
0.0189
-0.22
0.55
0.02
25.32
100.00
0.0238
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2024.68
-28.78
66.0
66.0
153.0
308.0
1.0
52.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0037670 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2
PMID32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32047258/
RECORD: Rec_0163932 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32047258/
RECORD: Rec_0268518 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2 PsV
PMID32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32047258/
RECORD: Rec_0364979 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | 293T/ACE2 cells
40 μM
No inhibition up to
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperFusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. | Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L. | Cell Mol Immunol. 2020 Jul;17(7):765-767. | DOI:10.1038/s41423-020-0374-2 | PMID:32047258 PMID32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32047258/
RECORD: Rec_0402185 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | Huh-7 cells
40 μM
No inhibition up to
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperFusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. | Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L. | Cell Mol Immunol. 2020 Jul;17(7):765-767. | DOI:10.1038/s41423-020-0374-2 | PMID:32047258 PMID32047258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32047258/