Peptide Database

Peptide NameSLAY-screened peptide P1305

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC100H139N21O27

DescriptionStandard

        HYLTFSNIPIAFLDTWE
    

Molecular Weight2067.30 Da

Isoelectric Point (pI)4.71

Net Charge (pH 7.0)-2.14

Net Charge (pH 7.4) -2.40

Charge Density (pH 7.0) -0.1262

GRAVY Index0.25

Hydrophobic Moment 0.33

Boman Index0.35

Instability Index48.99

Aliphatic Index 97.65

Aromaticity 0.2353

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 763.21

LogP -3.04

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 60.0

Heavy Atoms 148.0

Ring Count 7.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198250 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/