Peptide Database

Peptide NamehxlR signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC95H160N28O31S3

DescriptionStandard

        MSRMDDKRFNCEKELTLAV
    

Molecular Weight2286.65 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-0.50

Net Charge (pH 7.4) -0.74

Charge Density (pH 7.0) -0.0265

GRAVY Index-0.69

Hydrophobic Moment 0.31

Boman Index-0.30

Instability Index53.91

Aliphatic Index 61.58

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 995.71

LogP -9.72

H-bond Donors 36.0

H-bond Acceptors 34.0

Rotatable Bonds 81.0

Heavy Atoms 157.0

Ring Count 1.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0261494 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis subsp. subtilis str. 168 [Bacterium]

FamilyTat signal peptide

Tax ID224308

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity12250.0 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/