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MYP_076905
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Basic Information
peptide 10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KKWXKKWWK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055874 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=2-Nal (2-naphthylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
AT84
27.3±5.1 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0075492 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
k=D-Lys; X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0082181 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
A20
25.7±0.6 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0082648 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
X=Bip (Biphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer
AT84
29.3±7.8 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
RECORD: Rec_0088718 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
k=D-Lys; X=Dip (Diphenylalanine)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
347 μM
IC50
PaperDiscovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. J Med Chem. 2016 Apr 14;59(7):2918-27. doi: 10.1021/acs.jmedchem.5b02025. PMID: 26982623. PMID26982623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26982623/
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