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MYP_076902
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Basic Information
Api794 apidaecin petide derivative
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
22 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XWXWXWXRPVYXPRPRPPHPRL
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0116991 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,5,7,12; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 3227
16 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0121824 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,5,7,12; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae DSM 681
32 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0125129 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rat cardiomyocytes(IC50>0.6g/L)
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0139646 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,5,7,12; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Hemolytic
human RBC
0.1
Hemolysis
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0146250 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
gu = N
unspecified non-canonical residue at 1,3,5,7,12; N,N,N',N'-tetramethylguanidino, C-terminal OH, X= L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 1117
16 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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