Peptide Database

Peptide NameCyclotide hyen-M

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC134H213N33O43S6

DescriptionStandard

        SIPCAESCVWIPCTVTALLGCSCSDKVCYN
    

Molecular Weight3166.71 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.90

Charge Density (pH 7.0) -0.0532

GRAVY Index0.77

Hydrophobic Moment 0.28

Boman Index0.27

Instability Index30.74

Aliphatic Index 87.67

Aromaticity 0.0667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1190.75

LogP -13.38

H-bond Donors 47.0

H-bond Acceptors 48.0

Rotatable Bonds 95.0

Heavy Atoms 216.0

Ring Count 5.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0416387 VERIFIED: YES

Provenance & Taxonomy

Organismmedicinal herb Hybanthus enneaspermus [Plant]

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

TargetHuman red blood cells (hRBCs)

Activity50 μM

MethodHC50

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