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MYP_076898
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Basic Information
Cyclotide hyen-M
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C134H213N33O43S6
Standard
Sequence
SIPCAESCVWIPCTVTALLGCSCSDKVCYN
Physicochemical Analysis
3166.71 Da
4.37
-1.60
-1.90
-0.0532
0.77
0.28
0.27
30.74
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1190.75
-13.38
47.0
48.0
95.0
216.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051844 VERIFIED: NO
Provenance & Taxonomy
Hybanthus enneaspermus [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCyclotide hyen-M Evidence URLhttps://www.uniprot.org/uniprotkb/C0HLP7/entry
RECORD: Rec_0165580 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
K562
1.16±0.03 μM
CC50
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0247508 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
2.36±0.16 μM
CC50
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0258525 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
1.34±0.04 μM
CC50
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
RECORD: Rec_0400626 VERIFIED: YES
Provenance & Taxonomy
medicinal herb Hybanthus enneaspermus [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 32414842 PMID32414842 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414842/
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