Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length452 amino acids

Chemical FormulaC2249H3580N594O628S17

DescriptionStandard

        MARGADNTLRWATLVALAALGTAVTAAANPGIVARITQKGLDYACQQGVATLRKELEKITIPTFSGSFKIKYFGKGRYNFYSMVVREFKLPTSQIRLSPDRGLDLSIKDASVKISGKWKAQKNFIKASGNFDLSVEGISVLASLRLGYDPTSGHSTVSCSSCRSHINRVHVRTSGSSLKWLIQLFHRNIESALRKAMESKICKMLTNTVSSKLQPYFQTLPVTAKVDRMVGINYSLVAPPKATAENLDGLLKGEFFSLDHPSPPPFAPPALALPADHDRMVYLCISEYFFNTAGLVYQKAGVLNLTINNSMIPKKSLFSLTTNFFGTLIPKVSTMFPNMEMQFLIWASFPPHLAVHPSGLDLTFVLETQAFAVLPNASLAPLFLIEMNSSISVDIGVRSKRLIGELRLNNALTVGPVLLPDPQVELLQAVMNFAVPTLVLPKINGKELWGND
    

Molecular Weight49533.19 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)16.17

Net Charge (pH 7.4) 15.38

Charge Density (pH 7.0) 0.0358

GRAVY Index0.11

Hydrophobic Moment 0.81

Boman Index0.12

Instability Index29.60

Aliphatic Index 98.83

Aromaticity 0.0863

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0132549 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence