Peptide Database

Peptide NameHill-Knot 3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC138H238N46O41S6

DescriptionStandard

        RKCTASQCTRVCKKLGYKRGYCQSSTKCVC
    

Molecular Weight3390.04 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)7.69

Net Charge (pH 7.4) 7.39

Charge Density (pH 7.0) 0.2565

GRAVY Index-0.63

Hydrophobic Moment 0.64

Boman Index-0.35

Instability Index50.89

Aliphatic Index 35.67

Aromaticity 0.0667

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1471.04

LogP -20.34

H-bond Donors 61.0

H-bond Acceptors 55.0

Rotatable Bonds 117.0

Heavy Atoms 231.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0277875 VERIFIED: YES

Provenance & Taxonomy

OrganismHermetia illucens [Animal]

FamilyDefensin

Tax ID343691

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetA. fumigatus B42928

Activity32 μM

MethodIC50

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