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MYP_076770
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Basic Information
Cecropin A (1-13) + Melittin (1-13)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C136H232N34O32
Standard
Sequence
KWKLFKKIEKVGQGIGAVLKVLTTGL
Physicochemical Analysis
2855.51 Da
10.30
4.76
4.54
0.1830
0.27
0.80
0.16
-8.65
127.31
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1083.58
-5.06
38.0
37.0
102.0
202.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0317610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Escherichia coli
3.6
MIC
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
RECORD: Rec_0330324 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa OT97
1 μM
MIC
PaperPubMed PMID: 1733777 PMID1733777 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733777/
RECORD: Rec_0331068 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Escherichia coli D21 LC
0.5 μM
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
RECORD: Rec_0337917 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
D-[CA--M-NH2]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum F32 Tanzania
Percent inhibition; Microscopy (Acridine orange staining)
PaperAll-D amino acid-containing channel-forming antibiotic peptides PMID1693777 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1693777/
RECORD: Rec_0338298 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Candida albicans ATCC 32354
11.3
MIC
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
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