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MYP_076770
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Basic Information
Cecropin A (1-13) + Melittin (1-13)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C136H232N34O32
Standard
Sequence
KWKLFKKIEKVGQGIGAVLKVLTTGL
Physicochemical Analysis
2855.51 Da
10.30
4.76
4.54
0.1830
0.27
0.80
0.16
-8.65
127.31
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1083.58
-5.06
38.0
37.0
102.0
202.0
3.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0217936 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic
Sheep erythrocytes
200 μM
Inhibition zone
Paperhttps://pubmed.ncbi.nlm.nih.gov/2689223/ PMID2689223 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2689223/
RECORD: Rec_0227499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus Cowan 1
2 μM
MIC
PaperPubMed PMID: 1733777 PMID1733777 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733777/
RECORD: Rec_0246377 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Shigella flexneri ATCC 25875
4.2
MIC
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
RECORD: Rec_0248650 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
>300 μg/mL
HC50
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
RECORD: Rec_0258986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Shigella flexneri
4.7
MIC
PMID25130460 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25130460/
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