Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length489 amino acids

Chemical FormulaC2373H3802N612O696S15

DescriptionStandard

        MFLCCWLALGALIPLTLATDPGVKVKLTAKGLEYGRQLGMAAIQKKLKTIRVPDISGKASVSPIGTVQYSLTNLQIVDVGLPTSTVALVPGTGVRLSISKAFIRLDGNWRVKYLRIIKDSGSFDLNVSDLTVGASIAIKSDETGRPTVNSVGCEATVGSASIHFHGGASWLYNLFKDFIDKAIRDALQNQICPLVTDAVSDLNPQLKTLNVLAKVDQYAEIEYSMVSSPAVTTSSIELGLKGEFYNIGKRQEPPFSAAAFDLPPQTDNMLYVGLSAFTANSAAFVYSTAGALSLYVTDDMVPRASPIRLNTRTFGAFIPQIAERFPGLMVKLLVKTSETPVVTFEPNNTTVQATGTVTAYAIQPNATLSPLFVLNLESSASARLFVNVMRVAGNVTLNKMDLTLGTSYVGEFKVTALNSVFQMVLKSVVVPQLNVQLAKGYPLPTIGKMTLVNTKLQVLKGYMLIGTDVQFNSTHGASQDSFLPWGTTL
    

Molecular Weight52522.23 Da

Isoelectric Point (pI)9.04

Net Charge (pH 7.0)6.74

Net Charge (pH 7.4) 6.22

Charge Density (pH 7.0) 0.0138

GRAVY Index0.23

Hydrophobic Moment 0.79

Boman Index0.17

Instability Index25.59

Aliphatic Index 102.45

Aromaticity 0.0798

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298035 VERIFIED: NO

Provenance & Taxonomy

OrganismGasterosteus aculeatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence