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MYP_076607
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Basic Information
LP6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Proteasome inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protein prenyltransferase inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor
Immunology ▸ Immunomodulation ▸ Immunogenic
Immunology ▸ MHC/HLA binding
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
not Standard
1 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
X
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0413915 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
O=ornithine
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial Histidine-Rich Amphipathic Cationic Peptides
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0414494 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum D10
4 μM
IC50; ELISA (HRP-II levels detection)
PaperComprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon PMID18816382 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18816382/
RECORD: Rec_0414712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)16CO
Amidation
Ornithine at 1; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa MTCC 2295
>100 μg/mL
MIC
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0415335 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
Ramos
6.1 μM
IC50
PMID23085771 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23085771/
RECORD: Rec_0420581 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Z-L3-VS
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum 3D7
0.0164 μM
IC50; ELISA (HRP-II levels detection)
PaperComprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon PMID18816382 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18816382/
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