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MYP_076607
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Basic Information
LP6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Binding / Molecular interaction ▸ Binding activity
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Proteasome inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protein prenyltransferase inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor
Immunology ▸ Immunomodulation ▸ Immunogenic
Immunology ▸ MHC/HLA binding
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
not Standard
1 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
X
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0263819 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 53.3%, E 0.0%, T 20.0%, C 26.7% [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial Antifungal
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0270365 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis MTCC 2763
100 μg/mL
MIC
PMID33276980 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33276980/
RECORD: Rec_0272308 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Jamaicamide B
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
R=H, pyrrolinone ring& beta-methoxy enone
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 Indochina
18.4 μM
IC50; Fluorimetry (PicoGreen)
PMID17441769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17441769/
RECORD: Rec_0274337 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial Antibiotic
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0276284 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
N-(trans-epoxysuccinyl)
Guanidinobutyl amide
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum Δ4pfpm parasite line
2.1±0.2 μM
IC50; [3H] Hypoxanthine incorporation assay
PaperRole of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors PMID19752273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19752273/
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