MYP_076607
Basic Information
LP6
Anticancer
Anticancer Cytotoxic anticancer activity Cytotoxic
Antimicrobial
Antimicrobial Antibacterial
Antimicrobial Antibacterial Anti-Gram-negative
Antimicrobial Antibacterial Anti-Gram-positive
Antimicrobial Antibiotic activity
Antimicrobial Antifungal
Antiparasitic Anti-Leishmania Antileishmanial
Antiparasitic Antimalarial
Antiparasitic Antiprotozoal Antimalarial Anti-Plasmodium
Antiparasitic Antiprotozoal Anti-Trypanosoma
Antiparasitic General antiparasitic Antiparasitic
Antiviral
Binding / Molecular interaction Binding activity
Cardiovascular Blood pressure regulation Antihypertensive
Delivery / Targeting Cell penetration Cell-penetrating peptide
Delivery / Targeting Drug delivery vehicle
Enzyme modulation Enzyme inhibition ACE inhibition ACE inhibitory
Enzyme modulation Enzyme inhibition Proteasome inhibitor
Enzyme modulation Enzyme inhibition Protein prenyltransferase inhibitor
Enzyme modulation Enzyme inhibition Protein Synthesis Inhibitor
Immunology Immunomodulation Immunogenic
Immunology MHC/HLA binding
Toxicity / Safety Blood cell toxicity Hemolysis Hemolytic
Toxicity / Safety Cytotoxicity Cytotoxic
Venom / Toxin General toxin Cytotoxic
Venom / Toxin General toxin Toxic
Wound healing/Regeneration Angiogenesis modulation Angiogenic
not Standard
1 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
X
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000849 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)16CO
Amidation
Ornithine at 1; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 24433
>100 μg/mL
RECORD: Rec_0004294 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
N-(trans-epoxysuccinyl)
Guanidinobutyl amide
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum Δpfpm2 parasite line
3.0±0.2 μM
IC50; [3H] Hypoxanthine incorporation assay
RECORD: Rec_0008167 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
Labelled with fluoresceine/FITC
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
RECORD: Rec_0010832 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
Ramos
2.3 μM
IC50
RECORD: Rec_0011153 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protease/Proteasome inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Bio-Activity Profile
Antimicrobial Proteasome inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Dd2
0.0449 μM
IC50; ELISA (HRP-II levels detection)
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