Peptide Database

Peptide NameCathelicidin-3.4

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC166H247N49O28

DescriptionStandard

        RFRLPFRRPPIRIHPPPFYPPFRRFL
    

Molecular Weight3377.05 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.85

Net Charge (pH 7.4) 6.59

Charge Density (pH 7.0) 0.2633

GRAVY Index-0.70

Hydrophobic Moment 0.61

Boman Index-0.23

Instability Index141.27

Aliphatic Index 60.00

Aromaticity 0.2308

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1202.71

LogP -3.28

H-bond Donors 42.0

H-bond Acceptors 36.0

Rotatable Bonds 93.0

Heavy Atoms 243.0

Ring Count 15.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071578 VERIFIED: YES

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyCathelicidin

Tax ID9925

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa

RECORD: Rec_0140466 VERIFIED: NO

Provenance & Taxonomy

OrganismCapra hirca [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Hemolytic Anticancer

RECORD: Rec_0205598 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

RECORD: Rec_0228623 VERIFIED: NO

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyCathelicidin

Tax ID9925

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli

RECORD: Rec_0236928 VERIFIED: YES

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyCathelicidin

Tax ID9925

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

MethodHemolysis

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