Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC218H357N59O70S3

DescriptionStandard

        MKAVKEKKELFDLDVKVNAREISNSESDPPNTSLIWCTPGCAKNL
    

Molecular Weight5020.72 Da

Isoelectric Point (pI)6.10

Net Charge (pH 7.0)-0.51

Net Charge (pH 7.4) -0.77

Charge Density (pH 7.0) -0.0114

GRAVY Index-0.56

Hydrophobic Moment 0.48

Boman Index-0.11

Instability Index31.83

Aliphatic Index 78.00

Aromaticity 0.0444

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2106.00

LogP -22.08

H-bond Donors 72.0

H-bond Acceptors 73.0

Rotatable Bonds 170.0

Heavy Atoms 350.0

Ring Count 6.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413561 VERIFIED: NO

Provenance & Taxonomy

OrganismStaphylococcus capitis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence