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MYP_076534
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Basic Information
SmBz, cyclosporin A derivative
Antimicrobial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immunomodulation ▸ Immunosuppressive
not Standard
11 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
AXXXXXXXVXA
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188375 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
cyclosporin
29910
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: NMe-Leu; NMe-Val; NMe-Bmt; Abu; NMe-Gly
Bio-Activity Profile
Immunomodulating Antimicrobial
PaperThe genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster; Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment PMID23818858;30279281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23818858/
RECORD: Rec_0212999 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
unknown
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: NMe-Leu; D-NMe-Val; NMe-Bmt; Abu; NMe-Gly; Mnl
Bio-Activity Profile
-
RECORD: Rec_0239263 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
cyclosporin
29910
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: NMe-Leu; NMe-Val; NMe-Bmt; Abu; NMe-Gly; NMe-Ile
Bio-Activity Profile
-
PaperThe genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster; Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment PMID23818858;30279281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23818858/
RECORD: Rec_0248802 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Sarcosine (Sar)
Bio-Activity Profile
Antimicrobial Antifungal Immunosuppressive Antiparasitic Antimalarial
Plasmodium falciparum FCR3/Gambia, subline D
100 μg/mL
Percent reduction; Microscopy (Giemsa staining)
PMID6752020 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6752020/
RECORD: Rec_0255485 VERIFIED: YES
Provenance & Taxonomy
Tolypocladium inflatum [Fungus]
cyclosporin
29910
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: NMe-Leu; D-NMe-Val; NMe-Bmt; Abu; NMe-Gly
Bio-Activity Profile
Immunomodulating
PaperThe genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster; Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment PMID23818858;30279281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23818858/
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