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MYP_076420
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Basic Information
Arenicin-1 [R11A]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C124H188N38O25S2
Standard
Sequence
RWCVYAYVRVAGVLVRYRRCW
Physicochemical Analysis
2675.19 Da
10.30
4.74
4.50
0.2256
0.23
0.58
-0.07
67.80
97.14
0.2381
15470.00
15595.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1047.09
-4.44
44.0
32.0
80.0
189.0
7.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001359 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
18 μM
MIC
PMID21241661;20872168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
RECORD: Rec_0013803 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Arenicin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
12.5 μM
Hemolysis
PaperCho J, Lee DG. The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. Biochem Biophys Res Commun. 2011 Feb 18;405(3):422-427. doi:10.1016/j.bbrc.2011.01.046. PMID21241661 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
RECORD: Rec_0062494 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Arenicin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
25 μM
Hemolysis
PaperCho J, Lee DG. The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. Biochem Biophys Res Commun. 2011 Feb 18;405(3):422-427. doi:10.1016/j.bbrc.2011.01.046. PMID21241661 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
RECORD: Rec_0071534 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Arenicin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
50 μM
Hemolysis
PaperCho J, Lee DG. The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. Biochem Biophys Res Commun. 2011 Feb 18;405(3):422-427. doi:10.1016/j.bbrc.2011.01.046. PMID21241661 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
RECORD: Rec_0077077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
7 % hemolysis at 25 μM
Hemolysis
PMID21241661;20872168 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
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