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MYP_076417
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Basic Information
Bradykinin-potentiating peptide S3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Membrane / Ion-channel modulation ▸ Ion channel modulation
Regulatory peptide ▸ Biological modulation
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C64H94N18O17
Standard
Sequence
QGGWPRPGPEIPP
Physicochemical Analysis
1387.54 Da
6.00
-0.24
-0.44
-0.0182
-1.32
0.46
0.01
78.02
30.00
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
526.65
-4.20
15.0
17.0
34.0
99.0
7.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003124 VERIFIED: YES
Provenance & Taxonomy
Bothrops insularis [Animal]
Bradykinin-potentiating peptide S3
8723
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory
angiotensin-converting enzyme
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Bradykinin-potentiating peptide S3 (Bothrops insularis): PMID 11994001,22869554 PMID11994001;22869554 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11994001/
RECORD: Rec_0033868 VERIFIED: YES
Provenance & Taxonomy
Bothrops jararaca [Animal]
Bradykinin-potentiating peptide 13a
8724
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory
B2 receptor
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperBj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B₂ and M1 muscarinic acetylcholine receptors PMID21185808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185808/
RECORD: Rec_0064715 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Cytotoxic
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
RECORD: Rec_0072823 VERIFIED: YES
Provenance & Taxonomy
Bothrops jararaca [Animal]
Bradykinin-potentiating peptide 13a2
8724
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory
angiotensin-converting enzyme
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Bradykinin-potentiating peptide 13a2 (Bothrops jararaca): PMID 11994001,15922781 PMID11994001;15922781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11994001/
RECORD: Rec_0077383 VERIFIED: YES
Provenance & Taxonomy
Bothrops jararaca [Animal]
Bradykinin-potentiating peptide 13a
8724
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory
HEK 293 cells
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperBj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B₂ and M1 muscarinic acetylcholine receptors PMID21185808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185808/
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