Peptide Database

Peptide NameDrotrecogin alfa

Function Ontology

Antimicrobial

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length250 amino acids

Chemical FormulaC1249H1950N346O364S13

DescriptionStandard

        LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
    

Molecular Weight28053.79 Da

Isoelectric Point (pI)6.21

Net Charge (pH 7.0)-3.40

Net Charge (pH 7.4) -4.28

Charge Density (pH 7.0) -0.0136

GRAVY Index-0.27

Hydrophobic Moment 0.68

Boman Index0.03

Instability Index44.50

Aliphatic Index 88.88

Aromaticity 0.0800

Extinction Coeff. Reduced 58440.00

Extinction Coeff. Oxidized 58815.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049011 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCoagulation factor

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Coagulation factor replacement Enzyme replacement Anticoagulant Thrombolytic Fibrinolytic

Half-Life5.5 Hrs (Mammalian reticulocytes,in vitro

RECORD: Rec_0327265 VERIFIED: NO