Peptide Database

Peptide NameD4C3

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC165H255N49O26

DescriptionStandard

        FRFKIKFRLKFRFKARFKFRAKFRA
    

Molecular Weight3341.10 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)11.75

Net Charge (pH 7.4) 11.54

Charge Density (pH 7.0) 0.4702

GRAVY Index-0.57

Hydrophobic Moment 0.45

Boman Index-0.41

Instability Index-18.62

Aliphatic Index 43.20

Aromaticity 0.3200

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1289.24

LogP -4.52

H-bond Donors 50.0

H-bond Acceptors 38.0

Rotatable Bonds 117.0

Heavy Atoms 240.0

Ring Count 8.0

Amide Bonds 24.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0329870 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-FIV Release inhibition

TargetFeline immunodeficiency virus(FIV-Petaluma) | CrFK cells

Activity1.32 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperInhibitory activity of synthetic peptide antibiotics on feline immunodeficiency virus infectivity in vitro. | Ma J, Kennedy-Stoskopf S, Jaynes JM, Thurmond LM, Tompkins WA. | J Virol. 2002 Oct;76(19):9952-61. | DOI:10.1128/jvi.76.19.9952-9961.2002 | PMID:12208971 PMID12208971 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12208971/

RECORD: Rec_0354788 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic

FIRST PREV 1 2

Showing 2 records on this page Ã‚Â· Page 2 of 2