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MYP_076271
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Basic Information
Phakellistatin 18
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
7 amino acids
C45H63N7O9
Standard
Sequence
PYPIFPI
Physicochemical Analysis
846.02 Da
5.95
-0.04
-0.10
-0.0061
0.81
0.22
0.65
53.71
111.43
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
226.58
2.03
7.0
9.0
19.0
61.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0184814 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Toxin Cytotoxic Anticancer
Human hepatoma BEL-7404 cell line, BEL-7404 cell line
0.01 μg/mL
ED50
RECORD: Rec_0188280 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0197285 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0204007 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
(Not active up to 100 μg/ml)
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0271661 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116
3.9 μM
IC50
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
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