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MYP_076271
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Basic Information
Phakellistatin 18
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
7 amino acids
C45H63N7O9
Standard
Sequence
PYPIFPI
Physicochemical Analysis
846.02 Da
5.95
-0.04
-0.10
-0.0061
0.81
0.22
0.65
53.71
111.43
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
226.58
2.03
7.0
9.0
19.0
61.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019007 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
SK-HEP-1
7.7 μM
IC50
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0019203 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
(IC50=6.7 μM )
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0046504 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0103522 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-231
9.1 μM
IC50
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
RECORD: Rec_0149978 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
K562
33 μM
IC50
PMID20345147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20345147/
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