Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length434 amino acids

Chemical FormulaC2198H3420N546O632S14

DescriptionStandard

        MWTTIFQSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIKSPLFEDAGGADLFLSGVYFTGIVVLARNDFGHPILKLQRCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFLPVPFVLPERHDSMLYVGISEFFFKSASFAYFTSGAFNVTLSLKEISSHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASMVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSLLHFGILPLANAKLQQGIPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSLKQQLSFHGWEGLNLISGQWRGKPVA
    

Molecular Weight48054.85 Da

Isoelectric Point (pI)5.16

Net Charge (pH 7.0)-12.68

Net Charge (pH 7.4) -13.49

Charge Density (pH 7.0) -0.0292

GRAVY Index0.24

Hydrophobic Moment 0.63

Boman Index0.20

Instability Index40.21

Aliphatic Index 106.68

Aromaticity 0.1014

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0208779 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinus ursinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence