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MYP_076225
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Basic Information
Hylin-a1 (Hy-a1; Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C91H157N21O20
Standard
Sequence
IFGAILPLALGALKNLIK
Physicochemical Analysis
1865.35 Da
10.00
1.76
1.55
0.0977
1.50
0.48
0.54
11.98
190.00
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
644.36
-0.79
21.0
22.0
62.0
132.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110451 VERIFIED: YES
Provenance & Taxonomy
Boana albopunctata [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Enterococcus faecalis
PMID19056441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
RECORD: Rec_0115063 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
18 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/19056441/ PMID19056441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
RECORD: Rec_0118462 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecalis ATCC 29212
16 μM
MIC
PMID19056441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
RECORD: Rec_0141243 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Pseudomonas aeruginosa
64 μM
MIC
PaperHylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog").
RECORD: Rec_0142598 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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