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MYP_076225
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Basic Information
Hylin-a1 (Hy-a1; Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C91H157N21O20
Standard
Sequence
IFGAILPLALGALKNLIK
Physicochemical Analysis
1865.35 Da
10.00
1.76
1.55
0.0977
1.50
0.48
0.54
11.98
190.00
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
644.36
-0.79
21.0
22.0
62.0
132.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315275 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Hylin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
32.0 μM
MIC
PaperM.S. Castro et al. / Peptides 30 (2009) 291-296. Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog") Evidence URLhttps://www.uniprot.org/uniprotkb/P85982/entry
RECORD: Rec_0320064 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID19056441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
RECORD: Rec_0355064 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Bacillus subtilis
8 μM
MIC
PaperHylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog").
RECORD: Rec_0362036 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC 90028
16.7 μM
MIC
PMID19056441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
RECORD: Rec_0363324 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas albopunctatus [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
8
MIC
PMID19056441;33742508;20560142 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19056441/
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