Peptide Database

Peptide NameHylin-a1 (Hy-a1; Frogs, amphibians, animals)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiviral

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC91H157N21O20

DescriptionStandard

        IFGAILPLALGALKNLIK
    

Molecular Weight1865.35 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.0977

GRAVY Index1.50

Hydrophobic Moment 0.48

Boman Index0.54

Instability Index11.98

Aliphatic Index 190.00

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 644.36

LogP -0.79

H-bond Donors 21.0

H-bond Acceptors 22.0

Rotatable Bonds 62.0

Heavy Atoms 132.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012428 VERIFIED: YES

Provenance & Taxonomy

OrganismHypsiboas albopunctatus [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetparapsilosis ATCC 22019

Activity67 μM

MethodMIC

RECORD: Rec_0040769 VERIFIED: YES

Provenance & Taxonomy

OrganismBoana albopunctata [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0054505 VERIFIED: YES

Provenance & Taxonomy

OrganismHypsiboas albopunctatus [Animal]

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCryptococcus neoformans ATCC 90012

Activity33.5 μM

MethodMIC

RECORD: Rec_0078981 VERIFIED: YES

Provenance & Taxonomy

OrganismHypsiboas albopunctatus [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

RECORD: Rec_0085137 VERIFIED: YES

Provenance & Taxonomy

OrganismHypsiboas albopunctatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-negative

TargetE. coli

Activity32 μM

MethodMIC

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