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MYP_076128
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Basic Information
Citropin 1.1 M15
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C83H148N20O18
Standard
Sequence
GLFAVIKKVASVIKKL
Physicochemical Analysis
1714.19 Da
10.48
3.76
3.55
0.2348
1.18
0.77
0.30
-11.85
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
624.13
-1.76
22.0
22.0
61.0
121.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119194 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
53 μM
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
RECORD: Rec_0136739 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
3 μM
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
RECORD: Rec_0182189 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis VanA
8 μg/mL
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
RECORD: Rec_0204079 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Amphibian skin secretions
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Brain tumor cell line
5
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0226658 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
3 μM
MIC
PMID20564028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564028/
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