Peptide Database

Peptide NameSLAY-screened peptide P4316

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC61H99N17O22S

DescriptionStandard

        TFTCRPVTLTNDS
    

Molecular Weight1454.60 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-0.61

Net Charge (pH 7.4) -0.82

Charge Density (pH 7.0) -0.0470

GRAVY Index-0.26

Hydrophobic Moment 0.31

Boman Index-0.07

Instability Index45.08

Aliphatic Index 52.31

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 647.17

LogP -9.27

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 43.0

Heavy Atoms 101.0

Ring Count 2.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023230 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/